Antibiotic penetration in ear

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In , a larger study was published, which described characteristics of the penetration of an antibiotic through the middle-ear mucosa, not only in the first period after administration of the drug (input phase) but also in two subsequent periods, the steady-state phase and the output phase [5].

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The middle ear (ME) mucosa is a thin monolayer epithelium considered as a non-specialized site where antibiotics penetrate by passive diffusion through the capillary membrane in interstitial fluid. In the healthy ME mucosa, lipid-soluble molecules reachlower peak concentrations than in serum, but the penetration and diffusion profiles appear similar [ 2 ].


The middle ear mucosa is described as a non-specialized site where drug substances diffuse passively. However, precise pharmacokinetic studies on antibiotic penetration into middle ear effusion (MEE) are difficult to conduct in humans. The fluid may be thin like during a cold, or thick like pus. It is located in the middle ear, just behind the ear drum. Otitis media means inflammation of the middle ear.
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Oral antibiotics can cause more side effects than antibiotic eardrops. Side effects include diarrhea, nausea and vomiting, stomach pain, rash, headache, and dangerous allergic reactions. Who should use antibiotic eardrops? Antibiotic eardrops can be more effective and safer for: People with Swimmer’s Ear, an infection caused by water in the ear.

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Prompt oral antibiotic therapy, typically a fluoroquinolone, sometimes with an aminoglycoside plus a semisynthetic penicillin For an abscess, prompt incision and drainage Patients with diffuse inflammation of the entire pinna are given empiric antibiotics (eg, fluoroquinolones, which have good cartilage penetration) and often a systemic corticosteroid for its anti-inflammatory effects.

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